We investigate basic neuromuscular mechanisms mediating movements and their changes underlying both acute adjustments (e.g. muscle fatigue) and chronic adaptations (e.g. training, stroke) (movement neurophysiology). Moreover, we develop methods to restore, replace, and modulate lost or impaired motor functions (neurotechnologies). Our approach is interdisciplinary and is based on expertise in computer modeling (bioelectricity, biomechanics, neural networks), neural signal processing (machine learning), electrode and sensor design (high-density intramuscular and surface EMG electrodes), hardware design (multi-channel general-purpose amplifiers), neurophysiology of human movement (spinal circuitries, motor units and motor neurons, motor control modularity) and neurotechnologies (FES, BCI, robotics, active prostheses).
BIOELECTRODE AND BIOSENSOR DEVELOPMENT
We develop electrodes, sensors, and hardware systems for recording biosignals from nerves and muscles. Pioneering work has been specifically done in high-density muscle electrodes, both invasive (thin-film type) and non-invasive (flexible grids).
BIOSIGNAL ANALYSIS AND NEURAL DECODING
We develop algorithms for information extraction from neural signals. Pioneering work has been specifically performed on methods for efficient spike sorting of multi-channel, multi-unit signals, such as motor unit identification.
We develop models based on experimental neural signals and kinematics to estimate internal variables of human movements, such as joint moments and joint stiffness. We use these models to simulate the interaction between humans and neurotechnologies as well as to control assistive devices, such as lower-limb exoskeletons.
PROSTHETICS AND ORTHOTICS
We develop systems for replacing, restoring, neuro-modulating impaired motor function. The emphasis is mainly on upper and lower limb prosthesis, functional electrical stimulation, lower-limb exoskeletons, and brain-computer interfaces for inducing cortical plasticity.