We investigate basic neuromuscular mechanisms mediating movements and their changes underlying both acute adjustments (e.g. muscle fatigue) and chronic adaptations (e.g. training, stroke) (movement neurophysiology). Moreover, we develop methods to restore, replace, and modulate lost or impaired motor functions (neurotechnologies). Our approach is interdisciplinary and is based on expertise in computer modeling (bioelectricity, biomechanics, neural networks), neural signal processing (machine learning), electrode and sensor design (high-density intramuscular and surface EMG electrodes), hardware design (multi-channel general-purpose amplifiers), neurophysiology of human movement (spinal circuitries, motor units and motor neurons, motor control modularity) and neurotechnologies (FES, BCI, robotics, active prostheses).